交链孢酚单甲醚对人淋巴细胞内环核苷酸水平的影响  

Effect of AME on intracellular cyclic nucleotides levels in human lymphocytes

作　　者：李忠[1] 刘桂亭[1] 钱玉珍[1] 宫亚欧[1] 曹守廉 

机构地区：[1]河南医科大学病理生理教研室,河南医科大学食管癌研究室,郑州铁路卫校生物教研室

出　　处：《中国病理生理杂志》1994年第4期374-377,共4页Chinese Journal of Pathophysiology

摘　　要：淋巴细胞内环核苷酸水平的变化与免疫功能有关。交链孢酚单甲醚（ＡＭＥ）是食管癌高发区河南省林县粮食中分离的主要污染菌互隔交链孢霉（亦称链格孢菌）的毒素之一，已有实验证实ＡＭＥ具有致突变性和致癌性。本实验从体外探讨了ＡＭＥ对人淋巴细胞内环核苷酸水平的影响。实验结果表明，ＡＭＥ能增高淋巴细胞内ｃＡＭＰ水平，不同浓度的ＡＭＥ在不同作用时点上，使细胞内ｃＡＭＰ含量比相应对照组升高１．５～２．０倍，并且在同一时点，随ＡＭＥ浓度的增高，ｃＡＭＰ水平亦有增高的趋势。但ＡＭＥ对淋巴细胞内ｃＧＭＰ水平无显著影响。结果提示ＡＭＥ能提高淋巴细胞内ｃＡＭＰ水平，对细胞免疫功能可能有抑制作用。Intracellular cyclic nucleotides are related to immune function,Alternariol monomethylether(AME)is one of the mycotoxins from the main contaminative fungus.Alternaria alternataisolated from the mouldy grain in Linxian County where high incidence of esophageal cancer wasfound in Henan province.It has been shown that AME has mutagenicity and carcinogenicity. Theeffect of AME on intrilcellular cyclic nucleotides levels(in vitro)of human lymphocytes wasinvestigated.Results showed that AME could increase thc cAMP levels 1.5 to 2.0 times withdifferent concentration at different time points,and at the same time point with increase of AMEconcentration there was an enhance tendency. But therc was not any significant effect of AME oncGMP levels.The date suggested that AME could inhibit cellular immune by increasing the cAMPlevels in human lymphocytes.

关 键 词：链格孢属 真菌毒素 环核苷酸类 

分 类 号：R730.3[医药卫生—肿瘤]