p57^(KIP2)蛋白在肝细胞癌中的表达及意义  

Expression of p57^(KIP2) Protein in Hepatocellular Carcinoma and Its Significance

作　　者：朱星屹[1] 王广田[1] 庞志刚[1] 刘超[1] 赵玉洲[1] 薛飞[1] 孙建军[1] 

机构地区：[1]郑州大学第二附属医院,郑州市450014

出　　处：《医药论坛杂志》2005年第6期13-14,共2页Journal of Medical Forum

摘　　要：目的研究p57KIP2蛋白在肝细胞癌中的表达情况,并探讨其意义。方法应用免疫组织化学S-P法检测63例肝细胞癌石蜡包埋标本和38例癌旁组织中p57KIP2蛋白的表达情况。结果肝细胞癌p57KIP2的阳性表达率为46.0%,显著低于癌旁组织78.9%(P<0.01),并与肝细胞癌的病理分级、肿瘤大小、有无包膜及门静脉癌栓相关。结论p57KIP2蛋白表达的下调可能与肝细胞癌发生发展有关。Objective To investigate the expression of p57^(KIP2) protein in hepatocellular carcinoma cells and its significance. Methods p57^(KIP2) protein expression was detected by S-P immunohistochemistry in 63 tumor tissues of hepatocellular carcinoma and 38 adjacent hepatic tissues.Results p57^(KIP2) protein positive-expression rate in tumor tissue of hepatocellular carcinoma was 46.0%,which was significantly lower than 78.9% in adjacent hepatic tissues(P<0.01).It has lower expression in hepatocellular carcinoma with advance stage,larger size,poor capsula,portal embolus.Conclusion The down regulation of p57^(KIP2) protein may be related to the genesis and progress of hepacellular carcinoma.

关 键 词：肝细胞癌 P57^KIP2 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]