This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81672624 and 81772817), the Shanghai Municipal Health and Family Planning Commission of Science and Research Fund (Nos. 201540090 and 20164Y0274), the Fengxian District Science and Technology Committee Fund (No. 20170801), the Special Program for Collaborative Innovation in Shanghai University of Medicine & Health Sciences (No. SPCI-17-15- 001), the Innovation Fund from Joint Research Center for Precision Medicine set up by Shanghai Jiao Tong University & Affiliated Sixth People's Hospital South Campus (No. IFPM2016B001), and the Seed Fund Program of Shanghai University of Medicine & Health Sciences (Nos. HMSF-16-22-023 and SFP-17-22-15-030).
H3K4me3 and H3K36me2 histone demethylase KDM2B is an epigenetic regulatory factor involved in cell proliferation in numerous cells including breast cancer cells, however, the regulatory mechanism of KDM2B in cell prol...