低硒大鼠心肌细胞的钾通道  

Potassium channel in cardiac myocytes from Selenium deficiency rat heart

作　　者：鲍光宏[1] 于德洁[1] 刘宇[1] 徐理纳[1] 蔡求因 陈孝曙[1] 王淑琴[1] 李文仙[1] 

机构地区：[1]中国医学科学院基础医学研究所,中国预防医学科学院营养与食品研究所

出　　处：《中国地方病学杂志》1994年第3期142-145,共4页Chinese Jouranl of Endemiology

摘　　要：以含硒量低于０．０１２μｇ／ｇ的饲料喂养Ｗｉｓｔａｒ大鼠，形成低硒动物模型，用膜片箝技术记录动物模型心肌细胞的钾通道活动。用丹酚酸Ａ或亚硒酸钠可激活钾通道开放。用黄嘌呤／黄嘌呤氧化酶产生氧自由基作用于细胞膜可明显抑制钾通道开放。The animal model of Selenium deficient rat was set up by feeding Wistar rat with food containing Selenium lower than 0. 012μg/g. Potassium channel currents in single cardiac myocyte of Selenium deficient rat were recorded,using Patch-clamp techniques. Salvianolic acid A or sodium selenite activated potassium channels. Oxygen free radicals generated from reaction of xanthine and xanthine oxidase affected cell membrane and inhibited opening of potassium channels evidently.

关 键 词：钾通道 丹酚酸A 硒 心肌细胞 

分 类 号：R542.302[医药卫生—心血管疾病]