心肺转流术中红细胞抗氧化活性与机体氧化应激水平的关系  

Correlation Between the Activity of Erythrocyte Antioxi-dantion and the Level of Oxidant Stress During Cardiopul-monary Bypass

作　　者：顾家珍[1] 夏芳[1] 张遵严[2] 罗涛[1] 夏正远[1] 

机构地区：[1]武汉大学人民医院麻醉科,邮政编码武汉430060 [2]武汉大学人民医院胸外科

出　　处：《微循环学杂志》2005年第2期23-25,共3页Chinese Journal of Microcirculation

基　　金：国家自然科学基金课题 (3 0 47165 9)

摘　　要：目的:研究红细胞(RBC)抗氧化活性作为心肺转流术(CPB)患者氧化应激反应水平指标的可行性。方法:8例行主动脉-冠状动脉搭桥术的患者,分别于不同时相测定其中心静脉血中RBC抗氧化物丙二醛(MDA)和血浆游离异前列腺素15-F2t-Isoprostane(15-F2t-Imp)浓度。结果:在CPB和缺血再灌注损伤(IRI)过程中MDA产生明显增加,血浆游离15-F2t-Isop浓度显著增高,两者间存在明显正相关。结论:在CPB过程中,RBC抗氧化活性反映了机体氧化应激状态,是评价患者CPB时体内氧化应激水平的良好指标。Objective: To investigate whether red blood cell (RBC) antioxidant activity predicts alterations in oxidant stress during cardiopulmonary bypass (CPB) in humans. Method: 8 patients, scheduled for ACBP. Central venous blood was taken for evaluation of RBC antioxidant capacity (MDA) and to determine the concentration of plasma free 15-F2t-Isoprostane. Results: In IRI of process of CPB,the produce of MDA increased,also the concentration of 15-F2t-Isoprostane increased too. So that, There are clear correlation between the MDA and 15-F2t-Isoprostane. Conclusion: The antioxidant activity is to show the oxida-tive condition in organism with process of CPB. It may be to evaluate the level of oxidative stress in patients during IRI of process of CPB.

关 键 词：氧化应激水平 抗氧化活性 超氧歧化酶(SOD) 红细胞 缺血再灌注损伤 机体 术中 心肺功能障碍 氧化应激反应 心脏手术后 心肺转流术 异前列腺素 再灌注过程 实验研究 临床报道 临床评价 活性降低 开放手术 RBC MDA 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R282.71[医药卫生—临床医学]