Sumatriptan 治疗偏头痛的临床研究  

A CLINICAL TRIAL WITH SUMATRIPTAN IN PATIENTS WITH ACUTE MIGRAINE

作　　者：赵玉宾[1] 赵桂萍[1] 陈清棠[1] 韩殿良 马向平[3] 

机构地区：[1]北京医科大学第一医院神经内科,北京100034 [2]北京宣武医院神经内科,北京100050 [3]北京友谊医院神经内科,北京100050

出　　处：《中国临床药理学杂志》1994年第3期143-147,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：本文目的是验证Sumatriptan(英明格Imigran)治疗偏头痛的效果及安全性.采用随机双盲法,共观察105例偏头痛病人.研究结果表明:用Sumatriptan 6mg皮下注射,治疗偏头痛,镇痛效果令人满意.用于治疗一次性头痛,2h完全缓解率(头痛消失)达75%,与文献报道相符.除个别病例用药后有短暂大脑和植物神经功能紊乱症状外,绝大多数病人无不良反应.This clinical study is to evaluate the efficacy and safety of sumatriptan in patients withacute migraine. Sumatriptan was provided by Glaxo Limited Company. The clinical trial of randomized double - blind placebo controlled study, including 105 patients, was performed by the First Hospital of Beijing Medical University, Beijing Xuan Wu Hospital, and Beijing Friendship Hospital. The results indicatedthat subcutaneous injection of sumatriptan had good effect on patients with acute migraine. This drug produced complete relief of headache in 75. 0% of attacks within 2 hours. Complete relief plus marked improvement of headache accounted for 89. 3% of the attacks. Most of the patients had no adverse events except transient functional disturbances of the cerebrum and autonomic nervous system in a few patients.

关 键 词：偏头痛 SUMATRIPTAN 英明格 治疗 药物疗法 

分 类 号：R747.205[医药卫生—神经病学与精神病学] R972[医药卫生—临床医学]