壳聚糖-阿拉伯胶布洛芬缓释微囊制备工艺初探  

Studies on the Preparation Technology of Ibuprofen Microcapsules Using Chitosan and Acacia as Wall Materials.

作　　者：李榕 李柱来[2] 王津[2] 陈崇泽 刘玉树[2] 

机构地区：[1]长乐市医院药剂科,长乐350200 [2]福建医科大学药学院,福州350008

出　　处：《海峡药学》2005年第2期18-20,共3页Strait Pharmaceutical Journal

摘　　要：本文以壳聚糖和阿拉伯胶为囊材,采用复凝法将非甾族抗炎药布洛芬微囊化。探索了不同pH值、不同壳聚糖浓度、不同搅拌转速、不同成囊温度、不同浓度戊二醛固化交联剂对微囊制备工艺的影响:研究表明在PH值=4.0,壳聚糖浓度为0.3%,搅拌转速为200r·min-1,成囊温度为45℃,戊二醛用量为25%,1.0mL时制备的缓释微囊;具有囊型好、粒径分布均匀,包封率高且制备工艺稳定。The preparation technology of lbuprofen microcapsules with the complex coacervation using chitosan and acacia as wall materials was dealt in this paper.The effect of varities of technological condition such as different pH and concentration and reacting temperature.The stiteer speed linking reagent ect.c were explored.The result show that pH=4.0,C(chitosan)=0.3%,V=200r·min -1,T=45℃,V(pentanedial,25%)-1.0ml are the best technology.

关 键 词：壳聚糖 阿拉伯胶 布洛芬 微囊 包封率 

分 类 号：TQ460.4[化学工程—制药化工]