辛芩片对豚鼠鼻超敏反应的影响  

Influence of Xinqin tablets on guinea-pig nasal hypersensitivity

作　　者：张蓉[1] 余彦[1] 杜俊蓉[1] 刘剑[1] 张杰[1] 卫婷[1] 李欣[1] 李江[1] 龙锐[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《中国中药杂志》2005年第10期785-788,共4页China Journal of Chinese Materia Medica

摘　　要：目的:研究辛芩片对豚鼠鼻超敏反应的影响。方法:采用2,4二异氰酸甲苯酯(TDI)为致敏原,对豚鼠行鼻内给药建立鼻超敏反应实验模型,观察辛芩片对豚鼠鼻超敏反应模型鼻部症状、病理组织学及对鼻黏膜中组胺含量、一氧化氮合酶(NOS)活性的影响。结果:辛芩片能明显减轻鼻部症状及鼻黏膜病理改变,可显著降低鼻超敏反应模型豚鼠鼻黏膜中组胺的含量、抑制一氧化氮合酶的活性。结论:辛芩片对鼻超敏反应有显著疗效,可有效防治变应性鼻炎的发生。Objective: To study the influence of Xinqin tablets on guinea-pig nasal hypersensitivity. Method: 2,4-Toluene Diisocyanate (TDI) was selected as antigen and used in nose to establish guinea-pig allergic rhinitis. The effects of Xinqin tablets on symptoms of nasal hypersensitivity in guinea-pigs, histamine content of nasal mucosa and activity of nitric oxide synthase(NOS)were examined. Result: Xinqin tablets could significantly relieve the pathological symptoms of nasal hypersensitivity in guinea-pig, reduce histamine content of nasal mucosa and inhibit the activity of nitric oxide synthase. Conclusion: Xinqin tablets have significant effect on nasal hypersensitivity, and prevent the occurrence of allergic rhinitis.

关 键 词：鼻超敏反应 辛芩片 豚鼠 一氧化氮合酶(NOS) 二异氰酸甲苯酯 鼻部症状 反应模型 病理组织学 变应性鼻炎 鼻黏膜 实验模型 鼻内给药 组胺含量 病理改变 致敏原 活性 

分 类 号：R285.5[医药卫生—中药学]