人皮肤血管瘤组织中TGF-β_1、Cyclin D1的表达及相关性分析  

Association of TGF-β_1 and Cyclin D1 Expression in Human Dermal Hemangioma

作　　者：余方[1] 张端莲[1] 陕声国[2] 余瑛[1] 李红[1] 熊彦娥[1] 尹芳[1] 

机构地区：[1]武汉大学医学院组织学与胚胎学教研室,武汉430071 [2]武汉大学人民医院整形外科,武汉430060

出　　处：《武汉大学学报（医学版）》2005年第3期280-283,i004,共5页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助(编号:30271345);湖北省科技厅资助(编号:2003ABA164);湖北省卫生厅资助(编号:JXIB075)

摘　　要：目的:探讨TGFβ1、CyclinD1在血管瘤发生、发展过程中的表达状况及其意义。方法:采用免疫组织化学方法(SP法)检测人皮肤血管瘤增生期、退化期及其正常皮肤组织中TGFβ1、CyclinD1的表达水平,并进行相关性分析。结果:退化期血管瘤内皮细胞中TGFβ1表达水平明显高于增生期血管瘤组织,差异有显著性(P<0.05);增生期血管瘤内皮细胞CyclinD1表达水平高于退化期,差异有显著性(P<0.05);增生期和退化期TGFβ1和CyclinD1的表达均呈负相关(P<0.05)。结论:TGFβ1、CyclinD1通过影响血管瘤内皮细胞的增殖和血管生成而在血管瘤的病理演变过程中起着重要作用。Objective: To investigate the expression and significance of TGF-β 1 and Cyclin D1 in the occurrence and development of human hemangioma. Methods: The immunohistochemical method was used to detect the expression of TGF-β 1 and Cyclin D1 in the proliferating and involuting human hemangioma and normal skin tissues. Results: The expression of TGF-β 1 was significantly higher in the involuting hemangiomas than in the proliferating hemangiomas(P<0.05). While the expression of Cyclin D1 was significantly higher in the proliferating hemangiomas than in the involuting hemangiomas(P<0.05). The expression of TGF-β 1 and Cyclin D1 were closely associated in the proliferating hemangiomas and involuting hemangiomas(P<0.05). Conclusion: TGF-β 1 and Cyclin D1 play important roles in the mechanisms of hemangiomas pathological development through altering of endothelial cells proliferation and angiogenesis.

关 键 词：血管瘤 TGF-β1 CYCLIN D1 内皮细胞 

分 类 号：R732.2[医药卫生—肿瘤]