GSTM1基因缺失及吸烟与非小细胞肺癌的易感性  

A case-control study on relationship between absence of GSTM1 gene, smoking and susceptibility to non-small cell lung cancer

作　　者：乔贵宾[1] 孙长生[2] 李良寿[2] 曾伟生[1] 蒋仁超[1] 

机构地区：[1]广州军区广州总医院胸外科,广东广州510010 [2]第四军医大学预防医学系流行病学教研室,陕西西安710033

出　　处：《第四军医大学学报》2005年第11期1008-1010,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金(39670651);全军医药卫生"十五"科技基金课题(01Q023)

摘　　要：目的:探讨谷胱甘肽硫转移酶μ基因(GSTM1)缺失与肺癌遗传易感性的关系.方法:采用病例对照研究方法和PCR检测手段分析GSTM1基因缺失在213例病例和199例对照中的分布情况,并分析其与吸烟共同作用在肺癌发生中的作用.结果:GSTM1基因缺失率在肺癌病例组为61%,对照组为48%,OR=1.7(95%CI1.2～2.5),P=0.007.吸烟组肺癌患者与非肺癌患者相比,GSTM1基因缺失的OR=1.9(95%CI1.2～3.0),P=0.011.吸烟量≥30包×年的OR=5.9(95%CI2.6～13.0),P<0.01.结论:GSTM1基因缺失是肺癌发生的重要危险因素,吸烟与GSTM1基因缺失联合作用可增加患肺癌的风险,并有显著的剂量效应关系.AIM: To evaluate the role of absence of glutathione S-transferase M1 gene (GSTM1) in the susceptibility to smoking-related lung cancer. METHODS: A case-control study was designed and the absence of GSTM1 gene was detected with PCR technique in 213 cases and 199 controls. RESULTS: The absence of GSTM1 gene in the lung cancer group (61%) and controls (48%) was significantly different (P=0.007). Overall, the GSTM1 null genotype conferred a 70% increased risk of lung cancer, OR=1.7(95% CI 1.2-2.5, P=0.007). The absence of the GSTM1 gene encoding the glutathione S-tansferase M1 enzyme significantly increased the risk to people exposed to the carcinogens in tobacco smoke, OR=1.9(95% CI 1.2-3.0, P=0.011). People with GSTM1 genotype absence exposed to smoking of more than 30 packs×year had approximately six fold greater risk of cancer than people in the lowest risk group (nonsmokers with GSTM1 genotype present). CONCLUSION: GSTM1 plays an important role in the development of non-small cell lung cancer. GSTM1 null genotype is one of the major host factors of susceptibility to lung cancer.

关 键 词：肺肿瘤 疾病遗传易感性 谷胱甘肽硫转移酶μ基因 吸烟 

分 类 号：R730.2[医药卫生—肿瘤] R734.2[医药卫生—临床医学]