共轭亚油酸抗癌的安全性、有效异构体及其有效剂量  

Cinjugated linoleic acid against cancer:reliability,effective isomer and effective dosage

作　　者：刘霞[1] 

机构地区：[1]山东体育学院体育运动学校,山东省济南市250014

出　　处：《中国临床康复》2005年第18期212-213,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:回顾近年来共轭亚油酸在抗癌方面的研究进展,以便对这种脂肪酸进行深入研究。资料来源:应用Medline检索查找1980-01/2003-12期间共轭亚油酸抗癌方面的相关文献,利用万方数据库检索近4年国内期刊相关文献。检索词:共轭亚油酸(conjugatedlinoleicacid)。资料选择:选择共轭亚油酸抗癌的动物实验及体外细胞培养研究,作用机制研究以及人工合成方法等方面的相关文献45篇。资料提炼:在45篇文献中,经过严格筛选、分类,选取其中30篇用于分析,16篇作为参考文献。资料综合:共轭亚油酸有抗动脉粥样硬化作用,研究证实共轭亚油酸对乳腺癌、前列腺癌、结肠癌等有抗癌作用,并对多种体外培养的肿瘤细胞有抑制作用。共轭亚油酸有效的抗癌成分是c-9,t-11和t-10,c-12两种异构体,实验的有效剂量是0.1%～1.5%,并且与免疫调节、骨代谢等有关。结论:共轭亚油酸通过多种途径来发挥其抗癌作用。但在评价其安全性、有效异构体、有效剂量等方面,尚需进一步研究。OBJECTIVE:To review the progress in the research of anticarcinogenic effect o f conjugated linoleic acid(CLA)in recent years so as to perform further study on CLA. DATA SOURCES:The articles related to anticarcinogenic effect of CLA between J anuary 1980 and December 2003 in Medline and in the last 4 years in Wanfang data base were searched for using internet network both with the key words“ conjugat ed linoleic acid” . STUDY SELECTION:Totally 45 literatures were selected about anticarcinogenic e ffect of CLA using animal experiments,cell culture in vitro,mechanisms and synth etical methods of CLA. DATA EXTRACTION:After strict classification and selection to the 45 articles,30 were collected for analysis and 16 were used as referenced literatures. DATA SYNTHESIS:CLA had antiatherosclerotic function.Over the past two decades ,some anticarcinogenic effect have been attributed to CLA in experimental animal models including chemically induced mammary cancer,prostate cancer and colon ca ncer,and also showed the anticarcinogenic effect to cultured tumor cells in vitr o.The available isomeric composition for anticarcinogenic effect was c- 9,t- 1 1 and t- 10,c- 12.The available dosage was from 0.1% to 1.5% in exper iments .CLA was also associated with immunoregulation and bone metabolism. CONCLUSION:The proposed mechanisms of carcinogenesis by CLA varies in differe nt ways,but the evaluation of its reliability,available isomers and effective do ses needs further study.

关 键 词：共轭亚油酸 有效剂量 异构体 Medline检索 抗动脉粥样硬化作用 培养的肿瘤细胞 体外细胞培养 抗癌作用 数据库检索 资料来源 动物实验 合成方法 机制研究 参考文献 前列腺癌 抑制作用 抗癌成分 c-12 免疫调节 多种途径 

分 类 号：R735.2[医药卫生—肿瘤] R144.1[医药卫生—临床医学]