可乐定治疗溃疡性结肠炎160例临床分析  

Clinical Analysis of Treatment of 160 Cases of Ulcerative Colitis with Clonidine

作　　者：于信民[1] 尹祥敏[1] 刘庆民 孔晓霞[1] 孙凤芹[1] 田健[1] 柳玉萍[1] 董晓晖[1] 张锐利[1] 彭春雷[1] 侯亚莉[1] 孙荣钿[1] 

机构地区：[1]菏泽医学专科学校,274030 [2]菏泽地区人民医院

出　　处：《菏泽医学专科学校学报》1999年第1期17-19,共3页Journal of Heze Medical College

基　　金：山东省教委科技发展计划课题

摘　　要：目的　验证可乐定的抗溃疡性结肠炎（ＵＣ） 作用，并为ＵＣ 患者提供一味良好的治疗药物；方法　选择ＵＣ患者１６０ 例，随机分成治疗组和对照组，两组均定时检测结肠粘膜病理改变及临床症状变化，数据记入ＵＣ 追踪治疗记录表作Ｘ２ 检验；结果　可乐定组总有效率为９１ ．２５ ％ ，ＳＡＳＰ 组总有效率为８８ ．７５ ％ ，两组无显著差异（ Ｐ＞ ０ ．０５） ，但可乐定组溃疡愈合率、腹痛缓解率及里急后重消除率均优于ＳＡＳＰ 组（ Ｐ＜ ０ ．０５） ；结论　可乐定确有抗ＵＣ作用，可广泛推广应用，一般应从小剂量开始。Objective To verify the anti-UC effect of Clonidine and provide the patients with UC with a good medicine.Methods There were 160 patients with UC who were divided into two groups:the therapeutic group(clonidine,0.3mg tid 6 weeks in all)and the control group(SASP,1.5,tid 6 weeks in all).The pathologic changes and the change of clinical symptoms were tested regularly in two groups. The data were recorded in the recording list and the X 2 test was made. Results The total efficiency in the clonidine group was 91.25%,and in the SASP group 88.75%.There was no significant difference(P>0.05) between the two groups.But the ulcerative union rate,the abdominal pain remission rate and the tenesmic eliminatiou ratio in the clonidine group were all superior to those in the SASP group.Conclusion Clonidine has an anti-UC effect indeed. It is worth disseminating after the dose is suitable and has important social benefits.

关 键 词：可乐定 柳氮磺胺吡啶(SASP) 溃疡性结肠炎 临床分析 

分 类 号：R574.62[医药卫生—消化系统]