急性运动性轴索神经病冷冻复型超微结构观察  

Freeze Replica Ultrastructural Observation on Peripheral Nerve in Acute Motor Axonal Neuropathy

作　　者：吕佩源[1] 薛平[1] 宋春风[1] 杨程[1] 张玉英[1] 刘贵生[1] 

机构地区：[1]河北医学院附属第二医院神经内科,河北医学院电镜中心

出　　处：《中华物理医学杂志》1994年第3期145-149,共5页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：河北省自然科学基金

摘　　要：应用冷冻复型电镜技术对急性运动性轴索神经病（ＡＭＡＮ）周围神经病变特征与经典型格林－巴利综合征（ＧＢＳ）进行了对照研究．观察到前者以脊髓前根和远端周围运动纤维轴索不同程度病变为主，早期表现为神经微丝、微管数量较正常人和经典型ＧＢＳ者明显增多，经统计学处理有显著性差异（Ｐ＜０．０１）；经典型ＧＢＳ则以脊髓前、后根和远端周围神经纤维出现程度不等的髓鞘病变为主要特征，其早期病变者雪旺细胞核膜凹凸不平，核孔及核膜蛋白颗粒（ＩＭＰ）数量减少，并且板层粗糙或ＩＭＰ大小不一，分布不均。以上从亚细胞水平说明ＡＭＡＮ和经典型ＧＢＳ表现不同，为研究ＡＭＡＮ的特征提供了新的资料．The major change of peripheral nerve in acute motor axonal neuropathy(AMAN) were axonal lesion of varied severity in motor fibers. In axon of AMAN , the neurofilaments and neurotubules increased significantly in comparison with classical Guillain-Barre syndrome(GBS) (P<0.01). The classical GBS showed demyelination and disarrangement of lamellae structure of myelin sheath. In AMAN, enormous amount of intramembranous particles (IMP) existed on surface of myelin sheath and nuclear membrane of Schwann cell. However,less IMP of uneven size and distribution appeared on surface of corresponding structure in classical GBS. Especially the nuclear pores of Schwann cell were relatively apparent in AMAN. Our study suggested further that AMAN differs from classical GBS from the view point of biomembranous pathology of subcellular level.

关 键 词：轴索神经病 冷冻复型 超微结构 

分 类 号：R745[医药卫生—神经病学与精神病学]