Site discrepancy of synonymous codon usage in SARS coronavirus and other viruses in Coronaviridae  

SARS及其他几种冠状病毒密码子使用偏性的位点差异(英文)

作　　者：周童[1] 顾万君[1] 马建民[1] 孙啸[1] 陆祖宏[1] 

机构地区：[1]东南大学分子与生物分子电子学教育部重点实验室,南京210096

出　　处：《Journal of Southeast University(English Edition)》2005年第2期203-206,共4页东南大学学报（英文版）

基　　金：TheNationalNaturalScienceFoundationofChina(No. 60121101)

摘　　要：The synonymous codon usage in the translational initiation and termination regions of genes of severe acute respiratory syndrome (SARS) coronavirus and five other viruses in Coronaviridae was systematically analyzed.The results indicate that most minor codons for these coronaviruses are preferentially used in the initial and terminal region.The minor codons preferentially used in the initial region are thought to have a negative effect on gene expression,which can be explained by the minor codon modulator hypothesis.It also indicates that the minor codons preferentially used in the terminal region may regulate the level of gene expression.The proposed results strongly imply that the minor codon modulator hypothesis can be applied to both some bacteria and some viruses.分析了SARS冠状病毒以及其他5种冠状病毒基因编码起始区与终止区的密码子使用偏性.结果表明,冠状病毒基因组的稀有密码子倾向于出现在编码起始区和终止区附近.起始区的这种倾向性对冠状病毒基因的表达具有负性调控作用,可以用稀有密码子调控假说解释.终止区的这种倾向性表明,这些出现在终止区的稀有密码子对基因的表达也有负性调节作用.研究结果同时暗示了稀有密码子调控假说不仅适用于细菌,而且还适用于某些病毒基因组.

关 键 词：codon usage severe acute respiratory syndrome (SARS) CORONAVIRUS gene expression site discrepancy 

分 类 号：Q617[生物学—生物物理学]