原发性肝癌遗传与环境因素的病例对照研究  

Comprehensive Evaluation of Inheritance and Environmental Factors in the Etiology of Primary LiverCancer

作　　者：程兵[1] 王学良[1] 徐慧文[1] 门伯媛[1] 刘蓬勃[1] 

机构地区：[1]西安医科大学流行病学教研室

出　　处：《中华预防医学杂志》1994年第3期140-143,共4页Chinese Journal of Preventive Medicine

摘　　要：在１５２例原发性肝癌病人和１：１配对的对照中调查了与肝癌有关的危险因素，及家族中二系三级亲属肝癌的累积死亡情况。结果显示：病例组亲属肝癌的累积死亡率（０．４６％）明显高于对照组亲属（０．０７％）；病例组有血缘关系亲属中肝癌的累积死亡率（０．５５％）显著高于无血缘关系者（０．０８％）；而在有血缘关系的亲属中，随着血缘关系的疏远，肝癌的累积死亡率呈规律性的下降。用多元回归和分层分析法将遗传因素与其他环境因素综合分析后，仍可见到遗传因素的作用。这一结果为研究遗传因素与肝癌发病的联系提供了理论依据。A1:1 matched case-control study was carried out in 152 cases with primary liver cancer(PLC)and152 controls to identify the risk factors associated with it and its cumulative mortality in their second-andthird-degree relatives.Results showed cumulative mortality of PLC in the relatives of the cases(0.46%)was significantly higher than that of controls(0.07%).Cumulative mortality of PLC in consanguineousrelatives of the cases(0.55%)was significantly higher than that in non-consanguineous ones(0.08%)。Cumulative mortality of PLC decreased regularly with family relation(consanguinity) drifting apart.Genetic factors still played an important role independently in the etiology of PLC with multipleregression and stratification analyses studying genetic and environmental factors as a whole.This laid atheoretical basis to study further the association between genetic factors and PLC incidence.

关 键 词：肝肿瘤 遗传学 环境因素 

分 类 号：R735.7[医药卫生—肿瘤]