肝豆状核变性患者肝纤维化血清标志物的变化  

Changes of Serum Hepatic Fibrosis Markers Levels in Patients with Hepato-Lenticular Degeneration (HLD)

作　　者：吴君霞[1] 王蓉 韩红波[1] 何志超[1] 林祥宏[1] 许赣[1] 杨任民[1] 

机构地区：[1]安徽中医学院神经病学研究所附属医院检验科,230031 [2]合肥市蜀山区疾病控制中心检验科

出　　处：《放射免疫学杂志》2005年第3期171-173,共3页Journal of Radioimmanology

摘　　要：目的:探讨肝豆状核变性(HLD)患者的肝纤维化血清标志物:透明质酸(HA)、层粘蛋白(LN)和四型胶原(Ⅳ-C)的变化。方法:对186例HLD患者和39例正常对照组用放射免疫分析检测HA、LN和Ⅳ-C水平。结果:HLD组的HA、LN和Ⅳ-C水平分别为(175.12±73.81)μg/L、(128.60±21.36)μg/L和(87.98±32.74)μg/L显著高于正常对照组(P<0.01)。结论:HLD患者肝纤维化血清标志物水平显著升高,其均有不同程度的肝纤维化的存在。Objective To investigate the changes of levels of serum hepatic fibrosis markers hyaluronic acid (HA), Laminin (LN) and type Ⅳ collagen (Ⅳ-C) in patients with hepato-lenticular degeneration (HLD). Methods Serum HA, LN and Ⅳ-C levels were measured with RIA in 186 patients with HLD and 39 controls. Results In patients with HLD, the serum levels of HA (175.12±73.81)μg/L, LN (128.60±21.36)μg/L and Ⅳ-C (87.98±32.74)μg/L were significantly higher than those in controls (P<0.01). Conclusion Levels of serum hepatic fibrosis markers were significantly higher in patients with HLD, suggesting presence of hepatic fibrosis of some degree in these patients even without other evidences.

关 键 词：肝豆状核变性 血清标志物 肝纤维化 患者 正常对照组 HLD 透明质酸 四型胶原 层粘蛋白 分析检测 放射免疫 不同程度 Ⅳ-C 水平 HA LN 

分 类 号：R742.4[医药卫生—神经病学与精神病学] R512.62[医药卫生—临床医学]