血清游离多不饱和脂肪酸的组分变化与乳腺癌的关系  

A case-control study about the relationships between human breast cancer and seral free polyunsaturated fatty acids

作　　者：何永频[1] 陆瑞芳[1] 吴岷[1] 储云福 

机构地区：[1]上海医科大学营卫教研室,200032 [2]上海市粮食科学研究所

出　　处：《中国临床营养杂志》1999年第1期21-23,共3页Chinese Journal of Clinical Nutrition

摘　　要：采用气相色谱法测定了32例乳腺癌患者和24例对照组的血清游离多不饱和脂肪酸（PUFA）的组成。结果病例组n－6族的亚油酸（LA）、花生四烯酸（AA）及n-2族的小亚麻酸（ALA）、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的相对含量（％）分别为24．5、7．08、0．86、0．75和3．73，对照组分别为26．6、6．09、0．94、0．87和4．13。非配对t检验和x检验都表明病例组LA的相对含量显著低于对照组而AA显著较高（P＜0．05），但两组的n-3PUFA的相对含量均无显著差别。提示乳腺癌患者血清游离脂肪酸的组成模式有了某种程度的改变。Seral free polyunsaturated fatty acid (PUFA) compositions of 32 histologically diagnosed human breast cance patients (cases) and of 24 comparable non-cancerous women (control)were detected by gas-chromatography.It was found that the relative contents (percentages in total fatty acids) of two n-6 PUFAs like linoleic acid (LA), arachidonic acid (AA),and three n-3 PUFAs such as alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were averagely 24. 5,7. 08,0. 86,0. 75 and 3. 73 for the cases nrespectively;or were 26. 6,6. 09,0. 94,0. 87 and 4. 13 for the control respetively. Results of unpaired t-test as well as chi-square test show that the relaive content of LA in an is aignificantly lower than that in the control ,but it is opposite for AA (P<0. 05 for both);no significant difference between the two groups can be found for ALA,EPA and DHA. It suggests that Seral free PUFA compositions of breast cancer stifferers wight have been changed at some content.

关 键 词：多不饱和脂肪酸 二十二碳六烯酸(DHA) 组分 花生四烯酸(AA) 气相色谱法测定 亚油酸(LA) 血清游离脂肪酸 乳腺癌患者 相对含量 二十碳五烯酸 α-亚麻酸 X^2检验 配对T检验 PUFA 对照组 病例组 n-3 组成 

分 类 号：R151.2[医药卫生—营养与食品卫生学] R179[医药卫生—公共卫生与预防医学]