苯海索在精神科长期联合使用的必要性探讨  

A STUDY ON THE NECESSITY OF LONG TERM COMBINED USE OF BENZHEXOL IN PSYCHIATRY

作　　者：方贻儒[1] 王祖承[1] 黄继忠[2] 谢斌[2] 徐鹤定[2] 王士清[2] 苏炳华[3] 蔡秋艳[3] 

机构地区：[1]上海第二医科大学精神医学教研室,上海200030 [2]上海市精神卫生中心,上海200030 [3]上海第二医科大学生物统计学教研室,上海200025

出　　处：《中国药物依赖性通报》1994年第4期208-213,共6页

摘　　要：应用随机、双盲、平行交叉试验对48例因服用抗精神病药物出现锥体外系症状而联合应用苯海索持续3个月以上的患者,进行长期并用苯海索有否必要的探讨。结果发现:使用安慰剂期间,患者的精神症状、锥体外系症状及其自我体验与使用苯海索期间无明显差异;但迟发性运动障碍评分增加;撤药后,患者则表现出明显的“撤药症状”。作者认为,长期联合应用苯海索并无必要;相反要注意的是,长期并用可能导致患者的药物滥用及增加迟发性运动障碍的发生率。A random, double-blind, crossover trial was carried out on 48 patients who kept practising long term conbined use of benzhexol for more than 3 months due to extrapyramidal symptoms caused by antipsychotic drugs. The results showed that in the period of using placebo there was no statistical difference in psychological symptoms, extrapyramidal symtoms, and the self - assessment by patients themselves compared with those in the period of using benzhexol, but the scores of tardive dyskinesia rating scale increased. Meanwhile, when benzhexol was withdrawed, some withdrawal symptoms appeared in most patients, which suggested that long term combined use of benzhexol be unnecessary. Furthermore, attention should be paid to the problem of drug abuse and high prevalence of tardive dyskinesia induced by long term combined application of benzhexol.

关 键 词：苯海索 联合使用 迟发性运动障碍 精神科 锥体外系症状 抗精神病药物 交叉试验 精神症状 自我体验 撤药症状 药物滥用 患者 安慰剂 撤药后 发生率 期间 

分 类 号：R971.92[医药卫生—药品] R135.14[医药卫生—药学]