香菇多糖协同阿糖胞苷对HL-60白血病细胞增殖力的影响  

The Effects of Lentinan Polysaccharide and Ara-c on the Ability of HL-60 Cells Proliferation

作　　者：吴东红[1] 王翠莲[1] 张宇明[1] 陈永振[1] 

机构地区：[1]广东医学院附属医院,广东湛江524001

出　　处：《河北医学》2005年第8期710-712,共3页Hebei Medicine

摘　　要：目的:研究香菇多糖协同阿糖胞苷(Ara-c)对HL-60白血病细胞增殖力的影响。方法:观察HL-60细胞,分别经香菇多糖、Ara-c或香菇多糖协同Ara-c处理后,HL-60活性、抑制率及集落形成能力的变化,并与对照组(不含处理因素)比较。结果:香菇多糖协同Ara-c组HL-60细胞集落形成能力、增殖抑制率与其他三组比有显著差异,HL-60细胞活力与Ara-c组比无显著差异;香菇多糖组与对照组比各项指标均无显著差异。结论:香菇多糖能增强Ara-c对HL-60细胞的杀伤力。Objective:To study the effects of lentinan polysaccharide and Ara-c in the ability of proliferation on HL-60 cells. Method:Observing the activity, inhibited-rate and the colony-formation-ability of the HL-60 cells in lentinan polysaccharide-Ara-c group, lentinan polysaccharide group, Ara-c group and control group. Result: The differences in colony-formation-ability and inhibited-rate of the HL-60 cells between lentinan polysaccharide-Ara-c group and the other three groups were significant, but there is no difference in the activity when the former compared with the Ara-c group,also there is no difference between lentinan polysaccharide group and control group in each parametes. Conclusion:Lentinan polysaccharide helps to enhance the ability of Ara-c in killing the HL-60 cells.

关 键 词：香菇多糖 ARA-C HL-60 杀伤力 

分 类 号：R733.7[医药卫生—肿瘤]