宁德地区206例遗传咨询者细胞遗传学分析  

The chromosome analysis of 206 cases for genetic counseling in Ningde district.

作　　者：齐育英[1] 张捷[1] 郑新兰[1] 肖小慧[1] 陈依平[1] 

机构地区：[1]福建省宁德市医院检验科,352100

出　　处：《中国优生与遗传杂志》2005年第6期40-41,57,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨染色体异常在不良生育,习惯性流产,智力低下,发育异常和先天畸形等病人中的发生情况。方法取患者外周血进行淋巴细胞培养,常规收获,G显带,显微镜下进行核型分析。结果206例病人中共检出异常核型20例,异常检出率9.71%。结论结果表明染色体异常,多伴有多发畸形及智力低下,也是引起流产、死胎的重要原因。做好遗传咨询,将有助于减少先天缺陷儿的出生,对提高人口素质有重要意义。Objective: To investigate the distribution of the chromosome aberration among the cases of unhealthy birth, habitual abortion, low intelligence, abnormal growth and congenital deformity . Methods: Culture the blood in culture medium for lymphocyte and collect the cells in routine procedure, then analyze the karyotypes by G-banding technique. Results: The chromosome aberration was found in 20 of 206 cases for genetic counseling .The rate of abnormality was 9.71%. Conclusion:The chromosome aberration is the important factor caused recurrent abortion and dead fetus, and those who have chromosome aberration are likely with frequently-occurring abnormality and low intelligence . In order to lower the birth of congenital disease and improve the quality of population, it is necessary to develop the genetic counseling.

关 键 词：遗传咨询 染色体异常 核型分析 

分 类 号：R394[医药卫生—医学遗传学]