性发育和生育咨询患者染色体分析  

Chromosomal analysis in sexual development and bearing counseling

作　　者：邓明凤[1] 王昌富[1] 陈永玲[1] 袁琳[1] 张万胜[1] 张银汉[2] 

机构地区：[1]湖北省荆州市中心医院检验医学部,434020 [2]深圳市中心医院中心实验室,518035

出　　处：《中国优生与遗传杂志》2005年第6期42-43,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨具有性发育异常、原发性闭经以及不良孕产史患者染色体变化的有关特点和意义。方法染色体制备采用淋巴细胞培养,应用G、C等显带技术进行细胞遗传学分析。结果1098例性发育和生育咨询患者染色体异常检出率为6.47%;各组数目异常、性发育异常和原发性闭经患者结构异常多涉及性染色体;不良孕产史夫妇结构异常核型却以常染色体异常为主。结论20年工作表明,染色体分析十分必要,对于明确病因、鉴别诊断具有重要意义。Objective: To investigate the characteristic and significance of chromosome chang in sexual development abnormity, primary amenorrhea and cacoethic obstetrical history.Methods: The chromosomes were obtained by culturing of peripheral blood lympha cell and analyed under microscope after G-banding and C-banding. Results:The chromosome abnormality frequency is 6.47% in 1098 sexual development abnormity and bearing counseling peoples. In cacoethic obstetrical history couples,the most configuration abnormity are alteration of enchromosome and many others are sex chromosome alteration.Conclusion: It's necessary to examine the chromosome and importance for the diagnosis.

关 键 词：细胞遗传学 染色体 核型异常 

分 类 号：R394[医药卫生—医学遗传学]