三磷酸腺苷对人胃癌细胞系MGC－803影响的电镜观察  

EM OBSERVATION ON EFFECTS OF ATP ON HUMAN STOMACH TUMOR CELL LINE MGC-803

作　　者：吕桂芝 高燕 周立新 姚蓓 林仲翔 

机构地区：[1]北京市肿瘤防治研究所细胞生物学室

出　　处：《解剖学报》1994年第2期181-183,T014,共4页Acta Anatomica Sinica

基　　金：国家自然科学基金;北京市卫生局及测试基金

摘　　要：用透射电镜和扫描电镜方法观察了三磷酸腺苷（ＡＴＰ）对人胃癌细胞系ＭＧＣ－８０３的影响，结果表明，ＡＴＰ能使ＭＧＣ－８０３细胞的核仁由网状向环状改变，微丝的组装得到改善，细胞表面微绒毛减少。提示ＭＧＣ－８０３细胞的恶性表型在ＡＴＰ作用下可向正常方向逆转。In order to explore the effects of ATP on human stomach cancer cell line MGC-803,the morphological changes of this cell line following treatment with ATP were observed under TEM and SEM.It was found that the nucleoli of these cells were changed from reticulated form to ringshaped,the microfilaments became clearl and distributed more regularly,and the microvilli on cell surface were decreased markedly,These results sugest that ATP not only can inhibite the cell proliferation, but also can induce the reversion of malignant phenotype toward normal.

关 键 词：胃癌细胞系 MGC-803 腺苷三磷酸 

分 类 号：R73－36[医药卫生—肿瘤]