1969-2003年子宫内膜癌发病率及发病因素分析  

Year 1969-2003 Study on Evolution of Endometrial Cancer

作　　者：杨丹[1] 韩立敏[1] 

机构地区：[1]复旦大学附属中山医院妇产科,上海200032

出　　处：《复旦学报（医学版）》2005年第4期479-480,483,共3页Fudan University Journal of Medical Sciences

摘　　要：目的通过分析35年间子宫内膜癌的病例,了解子宫内膜癌发病在35年间的变化特点。方法回顾性分析中山医院1969年3月-2003年12月收治的子宫内膜癌病例209例,以年代为限分为3组,1969-1979年第1组25例,1980-1989年第2组41例,1990-1999年第3组57例,2000年1月-2003年12月为第4组86例。采用对照研究的方法回顾性分析4组病例占同期妇科住院病例的比例、对发病例数、发病年龄、生育和月经情况、合并高血压、糖尿病及肥胖进行比较分析。结果4组病例分别是同期妇科住院病例的0.39%、0.68%、0.84%和17.4%。第4组是第1、2、3组的44.6倍、25.6倍、20.7倍,第3组是第1、2组的2.2倍、1.2倍,第2组是第1组的1.7倍。子宫内膜癌病例数以每10年几何对数的速度增长,第4组的年平均数是第1组的10倍。发病年龄每10年增大1岁,P=0.0328。第3、4组流产数明显多于第1、2组P=0.036,P=0.003。第4组绝经年龄和行经年限增加P=0.0444,P=0.0020。第3、4组合并糖尿病、肥胖病例明显增加P=0.0114,P=0.0282。结论我国目前子宫内膜癌的病例增长迅速与国外一致,发病年龄并未年轻化,同国外相近。近10年糖尿病、肥胖发病率增加、绝经延后和行经年限增加是子宫内膜癌发病率增加的因素之一。Purpose To understand the features of the evolution of endometrial cancer during 1969-2003 in department of obstetrics and gynecology of Zhongshan hospital of Fudan University in Shanghai. Methods Two hundreds and nine women with endometrial cancer (from March 1969 to Dec.2003) were retrospectively analyzed.They were divided into 4 groups.There were 25 cases in the first group (1969-1979),41 cases in the second group (1979-1989),57 cases in the third group (1989-1999) and 86 cases in the fourth group (2000-2003).Their incidence rates,average ages,combined symptoms with hypertension,diabetes and obesity were compared and analyzed. Results These 4 group cases contain 0.39%, 0.68%,0.84%,and 17.4% of the total in hospital patients in the same peried.The percentage of the fourth group was 44.6,25.6,and 20.7 times more than the first,second,and third groups respectively.The percentage of the third group was 2.2,and 1.2 times more than the first and second groups respectively.The percentage of the second group was 1.7 times more than the first group.The incidences rate were continuously arising,the incidence of the fourth group were nearly ten times as the first one.Every 10 years,the average diagnosed age increased one year (P=0.032 8).Menopause of age and in time of menstruation (P= 0.044 4,P= 0.002 0),the combined symptoms with diabetes and obesity were significantly increased in the third and fourth groups (P=0.011 4,P=0.028 2). Conclusions The resulting change about incidence rate and average diagnosed age of this paper matches the results reported in United States.One of the factors may due to the continuously increased population with related higher risk factors like diabetes ,obesity and menopause of age and in time of menstruation.

关 键 词：2003年 癌发病率 因素分析 1980-1989年 1990-1999年 子宫内膜癌 回顾性分析 发病年龄 住院病例 2000年 糖尿病 变化特点 中山医院 对照研究 月经情况 比较分析 绝经年龄 病例数 高血压 肥胖 平均数 年轻化 妇科 同期 增长 

分 类 号：R735[医药卫生—肿瘤] R737.33[医药卫生—临床医学]