多梗塞性痴呆患者外周血CD54、CD106和CD62p的表达及意义  

Expression of peripheral blood CD54,CD106 and CD62p in patients with multi-infarct dementia

作　　者：吴杰[1] 尹金植[1] 刘佰纯[1] 丁萍[1] 姜立刚[1] 

机构地区：[1]吉林大学第二附属医院,长春130041

出　　处：《中国免疫学杂志》2005年第7期549-551,共3页Chinese Journal of Immunology

摘　　要：目的:探讨多梗塞性痴呆患者外周血CD54、CD106和CD62p的变化及意义。方法:采用酶联免疫法测定了8例多梗塞性痴呆患者血清CD54、CD106、CD62p水平,并与23例健康人对照比较。结果:多梗塞性痴呆患者血清CD54、CD10及CD62p水平(CD54:469±76.33ngml,CD106:1103.3±98.96ngml,CD62p:18.22±8.90ngml)较对照组(CD54:196±45.91ngml,CD106:601.0±76.30ngml,CD62p:6.70±3.30ngml)高,差异具有显著性意义。CD54、CD106及CD62p水平与痴呆程度呈正相关。结论:CD54、CD106、CD62p参与了MID的病理变化过程,并与痴呆程度密切相关,在一定程度上反映了MID神经功能缺损的程度,可作为MID后监测病情变化的重要指标。Objective:To investigate the expression of peripheral blood CD54,CD106,CD62p in patients with multi-infarct dementia.Methods:The levels of serum CD54,CD106,CD62P of 82 patients with multi-infarct dementia were measured with ELISA,and were compared with 23 normal controls.Results:The levels of serum CD54,CD106,CD62p in patients with multi-infarct dementia(CD54:469±76.33 ng/ml,CD106:1 103.3±98.96 ng/ml,CD62p:18.22±8.90 ng/ml) were higher than those in normal controls(CD54:196±45.91 ng/ml,CD106:601.0±76.30 ng/ml,CD62p:6.70±3.30 ng/ml). There were significant difference between the two groups.The levels of serum CD54,CD106,CD62p were positively correlated with the degree of dmentia.Conclusion:CD54,CD106,CD62p are closely related to the development of MID and play an important role in pathlogical procedure of cerebral damage after MID.The levels of CD54,CD106,CD62p in patients with MID implies the degree of their neurological function deficit scores and might be an important indicator to observe the changes of disease.

关 键 词：多梗塞性痴呆 CD54 CD106 CD62P 

分 类 号：R743.9[医药卫生—神经病学与精神病学]