小鼠不同锌营养状态对胸腺(九)肽的影响  

Effect of zinc on thymulin level in mice

作　　者：陈竞[1] 曲宁[1] 夏弈明[1] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所,北京100050

出　　处：《卫生研究》2005年第4期430-432,共3页Journal of Hygiene Research

摘　　要：目的观察小鼠不同锌营养状态对胸腺(九)肽的影响。方法在锌耗竭期,分低锌组(DC)(饲料含锌5.2mgkg)、对饲组(PZ)和正常锌组(饲料含锌25.6mgkg)。继后的锌补充期,分低锌组(DC)、低锌正常组(DZNZ)和对饲自由组(PZNZ)。动态观察血锌含量和胸腺(九)肽的含量。结果在血锌未发生明显变化时,胸腺(九)肽含量即随锌的耗竭而迅速下降,又伴随锌的补充而快速上升。结论胸腺(九)肽是锌营养状态变化的敏感指标。Objective\ In order to investigate the roles of the different levels of zinc nutrition status on the thymulin of the mice. Methods The experiment included two periods: zinc depleted period and repletion period. In the depleted period, mice were divided into 3 dose groups: zinc deficient group ~ZD, 5.2mg/kg), zinc pair-fed group ~PZ) and normal zinc group^NZ,25.6mg/kg). In the repletion period, mice were divided into 3 dose groups: ZD group, DZ-NZ group and PZ-NZ group.Results The results showed that a signification decrease of thymulin level was observed as a result of zinc deficiency and was increased rapidly follow zinc supplement, while the plasma zinc was kept the same level.Conclusion The thymulin is a sensitive biomarker for assess the zinc status.

关 键 词：锌 胸腺(九)肽 

分 类 号：R151.3[医药卫生—营养与食品卫生学] Q581[医药卫生—公共卫生与预防医学]