醇溶剂法制备高脱乙酰度壳聚糖  

Preparation of Highly Deacetylated Chitosan in Alcohol Medium

作　　者：宋庆平[1] 汪泳[1] 丁纯梅[1] 

机构地区：[1]安徽工程科技学院生化系,安徽芜湖241000

出　　处：《化学世界》2005年第7期422-423,433,共3页Chemical World

基　　金：安徽省教育厅自然科学基金重点项目(ah2003kj008zd)

摘　　要：采用戊醇氢氧化钠反应体系,通过对投料比、反应温度、反应时间等影响因素研究了甲壳素的脱乙酰反应,结果表明在四流温度,反应时间1.5h,壳聚糖:NaOH∶醇=1∶5∶11(质量比)条件下制得脱乙酰度为99.7%的壳聚糖,而传统水溶剂脱乙酰度小于50%。Using n-pentanol and sodium hydroxide as reaction medium,the influence of reactant ratio,reaction temperature and reaction time on the deacetylation of chitosan was studied.The results showed that chitosan of 99.7% degree of deacetylation was acquired under optimum reaction conditions: reflux temperature, 1.5 h, chitosan: NaOH:alcohol=1∶3∶16 mass ratio. In traditional methods using water as reaction medium,the deacetylation degree is lower than 50%.

关 键 词：甲壳素 壳聚糖 脱乙酰 醇溶剂法 

分 类 号：O636.1[理学—高分子化学]