偏头痛患者血小板功能异常及干预治疗的探讨  

An Investigation of Dysfunction of Platelet and Intervening Treatment in Migraine Patients

作　　者：王文红[1] 王雪松[1] 卢楠[1] 张春生[1] 

机构地区：[1]天津市第一中心医院神经内科,300192

出　　处：《中国全科医学》2005年第14期1134-1135,共2页Chinese General Practice

摘　　要：目的探讨偏头痛发作与血小板活化的关系并观察血小板抑制剂塞氯匹定(Ticlid)对血浆β-血小板球蛋白(β-TG)和血小板因子4(PF4)的影响。方法采用ELISA法对偏头痛发作期患者及正常对照者的血浆β-TG和PF4进行测定。结果(1)偏头痛组患者与对照者血浆β-TG和PF4的均值间差别均有显著性意义(P<0.001),并且两种因子增高呈正相关关系(r=0.49)。(2)Ticlid治疗前、后偏头痛患者血浆β-TG均值间差别有显著性意义(P<0.05),而PF4均值间差别无显著性意义(P>0.05)。而非Ticlid组患者治疗前、后血浆β-TG、PF4的均值间差别均无显著性意义(P>0.05)。(3)临床上经Ticlid治疗后头痛缓解的显效率为28%,有效率为40%,总有效率为68%。结论偏头痛的发作与血小板激活和释放有关,给予针对性的预防和治疗具有重要意义。Objective To discuss the relationship between the attack of migraine and the activation of platelets;and to observe the influence of Ticlid,the platelet inhibitive,on β-TG and PF4 of plasma.Methods We adopted the method of ELISA to determine the level of β-TG and PF_4 of plasma in the group of patients with migraine during attacks and the normal group.Results (1) In the group of migraine,the level of β-TG and PF_4 of plasma were both higher than the comparison group( P <0.001);at the same time,the two factors are positive-related ( r 0.49).(2) After treated with Ticlid,the concentration of β-TG decreased obviously compared with that before treatment( P <0.05).However,no significant change in statistics was found in the lower of the concentration of PF_4( P >0.05).(3) Meanwhile,the level of both β-TG and PF_4 of plasma had no significant change after treatment in the group without Ticlid( P >0.05).(4)The ratio of β-TG/PF_4,i n the comparison group and the migraine group before and after treatment,were all in normal range.The rate of improving is 28%.The effective rate is 40% and the total effective rate is 68%.Conclusion The attack of migraine has something connected with the activation and the release of the platelet,so it is important to give therapy and prevention.

关 键 词：偏头痛 Β-血小板球蛋白 血小板因子4 

分 类 号：R747.2[医药卫生—神经病学与精神病学]