IL-1β参与脑内核团诱发升压反应的机制  

Interleukin-1β involved in pressor response induced by intracerebral nucleus

作　　者：吕洋[1] 曲娴[1] 苏建军[2] 张成义[1] 赵华[2] 

机构地区：[1]北华大学医学院基础医学部生理学教研室,吉林吉林132013 [2]吉林大学基础医学院生理学教研室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2005年第4期553-556,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题(990566)

摘　　要：目的:研究白细胞介素1β(IL1β)对脑内核团诱发升压反应的作用。方法:将SD雄性大鼠随机分为对照组与实验组,利用脑立体定位微量注射系统给药,观察IL1β在室旁核(NPV)或弓状核(AR)诱发升压反应中的作用。结果:①室旁核或弓状核(尾端)内注入0.2ng的IL1β后血压明显升高,并伴有心率明显加快,与对照组比较差异均有显著性(P<0.01);②预先向双侧室旁核或弓状核注射抗IL1β抗体均能明显减弱由40nmol谷氨酸钠注入中央杏仁核所诱发的升压反应,但对其心率加快反应无明显影响(P>0.05),其血压变化值与注射煮沸的抗IL1β抗体后的血压变化值比较差异有显著性(P<0.01)。结论:下丘脑室旁核及弓状核内的IL1β均介导兴奋中央杏仁核诱发的升压反应。Objective To study the effects of interleukin-1β(IL-1β) on pressor response induced by intracerebral nucleus. Methods Male Sprague-Dawley rats were randomly divided into control groups and experimental groups. The stereotaxic microinjection system was used to inject IL-1β into hypothalamic paraventricular nucleus or arcurate nucleus, and the effects of IL-1β on pressor response induced by either of these two nuclei were observed. Results ①Microinjection of IL-1β (0.2 ng) into hypothalamic paraventricular nucleus or arcurate nucleus produced significant pressor and tachycardiac responses,there were significant differences compared with control group (P<0.01);②Preinjection of rabbit anti-interleukin-1β antibody into bilateral hypothalamic paraventricular nucleus or arcuate nucleus attenuated the hypertensive response induced by microinjection of 40 nmol sodium glutamate into central amygdaloid, but did not show significant effect on heart rate(P>0.05), and the change of blood pressure was significant when compared with boiled anti-IL-1β antibody (P<0.01). Conclusion Pressor effects of central amygdaloid nucleus are mediated by IL-1β in hypothalamic paraventricular nucleus or arcurate nucleus.

关 键 词：白细胞介素1 中央杏仁核 下丘脑室旁核 弓状核 谷氨酸钠 升压反应 

分 类 号：Q426[生物学—神经生物学]