t（8；21）急性髓细胞白血病──30例临床和实验室分析  

t(8;21) ACUTE MYELOID LEUKEMIA: AN ANALYSIS OF 30 CASES

作　　者：肖志坚[1] 郝玉书[1] 李建波[1] 冯宝章[1] 徐丽娟[1] 李幼升[1] 汤美华[1] 王建祥[1] 

机构地区：[1]中国医学科学院血液学研究所

出　　处：《中华血液学杂志》1995年第4期190-192,共3页Chinese Journal of Hematology

摘　　要：报告３０例ｔ（８；２１）急性髓细胞白血病（ＡＭＬ），２６例为Ｍ＿（２ｂ），４例为Ｍ＿（２ａ）。初始完全缓解率为０．９６２。０．７６２的男性患者伴有－Ｙ，０．２２２的女性患者伴有－Ｘ，０．２６７的患者伴有其它染色体异常。免疫表型分析ＨＬＡ－ＤＲ／ＤＰ阳性率０．１００，ＣＤ＿（３８）为０．８６６，ＣＤ＿（１５）为０．５００，ＨＩＭ＿４、ＨＩＭ＿５均为０．８００。ｔ（８；２１）ＡＭＬ与ＡＭＬＭ＿（２ｂ）的关系需进一步深入研究。hirty patients with t( 8;21) acute myeloid leukemia( AML) were analyzed.Their morphological diagnosiswere M_(2b) in 26 and M_(2a) in 4 cases,respectively.Thecomplete remission rate after initial induction chemother-apy was 9 6.2%. Sex chromosome loss was found in76.2%of male and 22.2%of female patients. In26.7%of the cases there were other additional chromo-some abnormalities.For immunophenotypes,HLA-DR/DP was positive in 1 00%,CD_(38) in 86.5%, CD_(15) in 50. 5%,and HIM_4 and HIM_5 both in 80.0% patients. Therelationship between t ( 8;21) AML and AML M_(2b) isworth further researching.

关 键 词：白血病 髓细胞性白血病 染色体异常 免疫表型 

分 类 号：R733.7[医药卫生—肿瘤]