多胺与缺血性神经元损伤的关系及三种药物对神经元的保护作用  

Relationship between polyamine and ischemic neuronal damages;Protective effects of nomodipine,MK-801 and baclofen

作　　者：郑彩梅[1] 黎红华[1] 吕智勇[1] 

机构地区：[1]第三军医大学附属西南医院神经内科

出　　处：《第三军医大学学报》1995年第3期217-219,共3页Journal of Third Military Medical University

摘　　要：本实验观察全脑缺血大鼠不同再灌流期脑部多胺含量与缺血性神经元损伤的关系，以及Ｎｉ－ｍｏｄｉｐｉｎｅ、ＭＫ－８０１、Ｂａｃｌｏｆｅｎ治疗对它们的影响。结果发现，腐胺与再灌流神经元损伤密切相关，三种药物均能保护神经元，减轻缺血性损伤，而且又使腐胺含量降低，讨论了作用机理。The relationship between polymaine and ischemic neuronal damages was studied in rats during ischemia and periods with different reperfusion.Meanwhile,the protectie effects of nimodipine,MK-801 and baclofen on the neurons were obsered,It was found that polymaine played an important role in the delopment of reperfusion damages of neurons and all the 3 agents could protect the neurons to alleiate their ischemic damages and to decrease their putresceine level,The mechanism of their therapeutic effects was discussed.

关 键 词：多胺 神经元损伤 钙拮抗剂 NIMODIPINE MK-801 

分 类 号：R745.02[医药卫生—神经病学与精神病学] R322.85[医药卫生—临床医学]