氚标记(+)与(-)棉酚在大鼠主要脏器的亚细胞分布及共价结合  

THE SUBCELLULAR DISTRIBUTION AND COVALENT BINDING OF ~3H-(+) AND ~3H—(-) GOSSYPOL IN THE MAIN TISSUES OF RATS

作　　者：邓惠玲[1] 於毓文 吴大方 仪明光 

机构地区：[1]中国医学科学院药物研究所,北京100050 [2]中国科学院原子能研究所,北京102413

出　　处：《药学学报》1989年第7期490-495,共6页Acta Pharmaceutica Sinica

摘　　要：给大鼠腹腔及睾内注射氚标记的(+)与(-)棉酚后第7、18天,对主要脏器中各亚细胞组分的总放射活性及共价结合的放射活性进行了动态观察。结果表明,(-)棉酚在心肌线粒体共价结合放射活性较明显高于(+)棉酚;(+)及(-)棉酚在睾丸细胞膜、微粒体共价结合的放射活性随时间增高,且(-)棉酚较为明显。The total and covalently bound radioactivity in various subcellular components in the main tissues of rats was measured 7 and 18 days after a single intraperitoneal and intratesticular injection of 3H-(+) and 3H-(-) gossypol. An increasing tendency of covalently bound radioactivity with time in the myocardial mitochondria and tcsticular cell membrane and microsomes of rats treated with (+) or (-) gossypol was found, especially in (-) gossypol treated rats. It remains to be clarified whether these arc linked to the myocardial toxicity and to the antispcrmatogenic activity of gossypol.

关 键 词：棉酚 亚细胞组分 共价结合 

分 类 号：R914.2[医药卫生—药物化学]