人染色体脆性部位3p14扫描电镜的初步观察  

A Preliminary investigatiom of Human Chromosomal Fragile Site 3p14 Using Scanning Electron Microscopy (SEM)

作　　者：曹来蓉[1] 董孝詠 苏爱[1] 邹国祥[2] 王济中[2] 

机构地区：[1]青岛医学院生物教研室 [2]青岛医学院电镜室

出　　处：《Acta Genetica Sinica》1989年第6期483-485,共3页

摘　　要：本文对人外周血淋巴细胞染色体最常见的脆性部位3P14进行了扫描电镜的初步观察。发现电镜下fra(3P14)的单体断裂或裂隙可能为DNA纤维的包装不全图象,并表现出不同形态特征。A preliminary scanning electron microscopical observation on the most common human chromosomal fragile site 3pl4 of the peripheral lymphocytes was reported.It was shown that chromatid break or gap at 3p14 observed under SEM may be a sign of under-packing of DNA filaments and the possibility of various packing-patterns might be in existance.The result of the present work might be of significance in the understanding of natures of breaking or gap of chromatid and may be of help to the study of the mechanisms of chromosomal fragile site formation.

关 键 词：染色体 脆性部位 扫描电镜 

分 类 号：R730.43[医药卫生—肿瘤]