纤维结合素多肽衍生物的化学合成及对骨髓瘤细胞株K562的体外抑制作用  

Chemical synthesis of hexapeptide derived from fibronectin and its inhibition function on myeloma cell K562 in vitro

作　　者：王洪海[1] 陈佩丽[1] 焦顺昌[1] 周严恒[1] 

机构地区：[1]复旦大学,解放军总医院,复旦大学遗传学研究所

出　　处：《复旦学报（自然科学版）》1995年第4期404-408,共5页Journal of Fudan University：Natural Science

摘　　要：应用固相多肽合成技术，人工合成了一种衍生于纤维结合素的六肽ＧＲＧＤＳＳ。用高效液相层析进行纯度鉴定，并观察六肽对骨髓瘤细胞株Ｋ５６２的体外抑制作用。实验结果表明，六肽在７２ｈ内对骨髓瘤细胞的抑制率为３１％；多肽的结构对功能有一定的影响。根据竞争抑制原理，设计和合成多功能的多肽可为临床医学治疗肿瘤开辟一个新的途径。he paper has reported that hexapeptide derived from fibronectin was synthesized in solid-phase peptide synthesis strategy and its inhibition effect on myeloma cell in vitro. The inhibition rate of myeloma cell K562 by synthetic hexapeptide was 30% or so in 72 hours. The design of multifunctional peptides capable of recognizing specific substrates according to competitive inhibition could lead to reagents for the use in medicine.The application of synthetic peptide to treat tumor may put forward a new route to cure the cancers.

关 键 词：合成 多肽 纤维结合素 骨髓肿瘤细胞 抑制作用 

分 类 号：TQ464.7[化学工程—制药化工] R733.2[医药卫生—肿瘤]