绿茶对实验性大肠癌抑制作用的研究  

THE INHIBITORY EFFECT OF GREEN TEA ON LARGE INTESTINE CANCER INDUCED BY 1,2-DMH

作　　者：银平章[1] 程书钧[1,2] 赵进英[1] 祝庆蕃[1,3] 刘政国[1] 孔令非[1] 徐继跃[1] 张广甫[1] 党伟一[1] 吴凯彦[1] Y.Hara 

机构地区：[1]河南省人民医院病理科 [2]中国医学科学院肿瘤研究所 [3]河南医科大学

出　　处：《河南医学研究》1995年第2期164-167,共4页Henan Medical Research

摘　　要：本实验观察了绿茶儿茶素对１，２－ＤＭＨ诱发小鼠大肠癌的影响，结果显示：①绿茶多酚及绿茶水溶性提取物对１，２－ＤＭＨ诱发Ｃ＿５７ＢＬ小鼠大肠隐窝上皮细胞徽核及凋谢有明显的拮抗作用。本实验所用微核及凋谢的测定方法是一种简便、快速而且经济的抗结肠致癌物筛选方法。②绿茶几茶素对大肠癌有预防作用，其抗癌机制可能与绿茶儿茶素成分中超氧化物歧化酶及其它抗氧化剂清除癌组织中自由基有关。In this study,we observed the effects of green tea catechin on large intestinecancer induced by 1,2-DMH in mice. Our results indicated that①the green tea polyphenolsand green tea water extract had distinct antagonistic effect on micronuleus and apoptosis inthe colon crypt cells of C-(57) BL mice.The method used in this study might be a simple,rapideconomical and useful test in the screening of anticolon carcinogens. ②green tea catechinhave preventive effects on large intestine cancers. Their anticancerous mechanism may be re-lated to the antagonistic effect of SOD and other anti-oxidizers in green tea catechin on free radicals in cancer.

关 键 词：绿茶儿茶素 大肠肿瘤 

分 类 号：R735.340.5[医药卫生—肿瘤] R965[医药卫生—临床医学]