粘细菌发酵生产新型微生物药物的初步研究  

A New Kind of Microbiological Drug Produced by Fermentation of Myxobacteria

作　　者：罗立新[1] 汪薇[1] 潘力[1] 

机构地区：[1]华南理工大学生物科学与工程学院

出　　处：《食品与发酵工业》2005年第7期10-12,共3页Food and Fermentation Industries

基　　金：广东省自然科学基金资助项目(031357)

摘　　要：通过在家兔粪粒上诱导出子实体,转接到固体培养基中,使之发展为菌落,再挑取菌落边缘的培养物来分离纯化粘细菌。在利用纤维堆囊菌发酵生产埃坡霉素(Epothilone)的工艺中,添加环式糊精到发酵培养基中,并在获得的发酵液中添加吸附树脂,简化了产物的提取工艺。In this study, a method to induce fruiting bodies formed from sterile rabbit dung was used for isolation and purification of Myxobacteria as it does not disperse easily in liquid media. The fermented compound containing epothilones could be easily extracted by adding cyclodextrin to culture medium.

关 键 词：粘细菌 分离 纤维堆囊菌 代谢产物 发酵生产 微生物药物 提取工艺 固体培养基 发酵培养基 分离纯化 

分 类 号：TQ450[化学工程—农药化工]