胃癌高发区粮食提取液对人胚胃影响的实验研究  

ExperimentalStudyonEffectofCornflourLiguidExtractinHighRiskAreaof GastricCarcinoma onHumanFetalHastricMucosa

作　　者：高泽立[1] 王凤荣[1] 谢国欣 左连富[1] 李定国[1] 

机构地区：[1]上海第二医科大学新华医院,河北医学院

出　　处：《实用癌症杂志》1995年第2期73-75,共3页The Practical Journal of Cancer

摘　　要：为了调查研究高发区胃癌的病因学，作者收集了赞皇县的玉米面样品作实验研究。将玉米面提取液加入器官培养的人胚胃粘膜进行形态学观察和流式细胞测定，结果表明，在培养２天和１０天后Ｓ期细胞数和细胞增殖指数（ＰＩ）明显增加，４２天后有些细胞发生形态学变化，具有某些恶性特征。采用高效液相色谱分析发现，在玉米面提取液中有杂色曲霉毒素和黄曲霉素Ｂ２。曲霉毒素的检出率和平均含量在胃癌高发区和相对低发区之间有显著差异。作者认为，真菌及其毒素可能是胃癌的重大病因之一。In order to investigate the etiology of gastric carcinoma in the high Tisk area , the authors collectedthe samples of cornflour from Zanhuang county , HebeiProvince. The cornflour liguid extract was added to humanfetal gastric mucous Of organ culture in vitro for morphologicalobservationand analysing by flow cytometry. Theresults showed that after 2 days and l0 days the numb er of s- phase cells and proliferation index(PI)inereased. After4 2 days, a few cells showed some changes in morphology a nd had some maligna n t cha rac teristics. Analysed w ith highp erformance liguid chromatography , sterigmatocystin and aflatoxinB2 were found in cornflour extract. Positive rateand a verage a mou nt of mycotoxin b etween high risk a rea of stomach cance r and rela tively lower risk area weresign ifican tly differe nt.It is suggested that fungus and mycotoxin may be one of the importa n t causes of stomachcancer .

关 键 词：胃肿瘤 真菌毒素 流式细胞测定 

分 类 号：R735.2[医药卫生—肿瘤]