Recent progress report on DNA B-Z transition modulated by rare earth-amino acid complex and Alzheimer's disease amyloid beta  

作　　者：耿杰 曲晓刚 

机构地区：[1]State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry [2]Graduate School of the Chinese Academy of Sciences

出　　处：《Journal of Rare Earths》2010年第6期820-823,共4页稀土学报（英文版）

基　　金：Project supported by the NSFC (20831003, 90813001, 20903086);Funds from CAS

摘　　要：Rare earth elements have unique physical, magnetic, luminescent and catalytic properties. They have been successfully used as medicine and probes in luminescent resonance energy transfer (LRET) for bioassays, as well as reagents for diagnosis in magnetic resonance imaging (MRI). In this progress report, we will focus on recent progress on how rare earth amino complexes bind to DNA and change DNA structure, especially on DNA B-Z transition induced by rare earth amino acid complex and its potential impact on Alzheimer’s disease (AD).Rare earth elements have unique physical, magnetic, luminescent and catalytic properties. They have been successfully used as medicine and probes in luminescent resonance energy transfer (LRET) for bioassays, as well as reagents for diagnosis in magnetic resonance imaging (MRI). In this progress report, we will focus on recent progress on how rare earth amino complexes bind to DNA and change DNA structure, especially on DNA B-Z transition induced by rare earth amino acid complex and its potential impact on Alzheimer's disease (AD).

关 键 词：DNA Z-DNA CONFORMATION amyloid beta Alzheimer's disease rare earths 

分 类 号：R749.16[医药卫生—神经病学与精神病学]