肺腺癌患者外周血及肿瘤浸润性淋巴细胞中Fas分子的表达及意义  

Expression and significance of the Fas molecule in tumor infiltrating and peripheral blood lymphocytes in patients with lung adenocarcinoma

作　　者：楚广民[1] 马艳英 

机构地区：[1]河南省肿瘤医院病理科,郑州450008

出　　处：《中国实用医刊》2010年第2期30-32,共3页Chinese Journal of Practical Medicine

摘　　要：目的 检测Fas分子在肺腺癌患者肿瘤浸润淋巴细胞(TILs)和外周血淋巴细胞(PBLs)中的表达,探讨Fas/FasL在肿瘤局部与全身免疫反应中的作用及临床意义.方法 用流式细胞术(FCM)对50例肺腺癌患者PBLs及TILs中Fas的表达进行定性定量分析,以48例正常人的PBLs为对照组.结果 Fas分子在肺腺癌患者TILs和PBLs中的表达率分别为16.8%和8.0%,对照组PBLs为12.6%,前者表达率明显高于后两者(P<0.05);而肺腺癌患者PBLs的Fas分子表达率明显低于对照组PBLs(P<0.05).结论 Fas分子在肺腺癌患者PBLs与TILs及其亚群中的表达不同,Fas/FasL在机体肿瘤局部及全身水平的免疫反应中起着重要作用.Objective To study the Fas expression in tumor infiltrating lymphocytes (TILs)and peripheral blood lymphocytes(PBLs) from patients with pulmonary adenocarcinoma, and to investigate the clinical significance and the role of the Fas/FasL in local and systemic immune responses. Methods By flow cytometery(FCM),the expression of Fas molecule were detected on TILs and PBLs in 50 cases of lung adenocarcinoma and in 48 cases of normal healthy PBLs. Results Expression rate of Fas molecule on TILs and PBLs of lung adenocarcinoma patients was 16.8% and 8.0% respectively,and on PBL of normal controls was 12.6%. The former was significantly higher than the two latters(P<0.05). Expression rate of Fas molecule on PBLs of lung adenocarcinoma patients was significantly lower than the control group (P<0.05). Conclusions Expression of the Fas molecul on TILs and PBLs of lung adenocarcinoma patients is different. Fas/FasL pathway plays a major role in the fighting between immune system and tumor not only at local tumor site but also at systemic level.

关 键 词：癌患者 外周血淋巴细胞 肿瘤浸润性淋巴细胞 FAS分子 表达率 lung ADENOCARCINOMA peripheral blood TILs Fas/FasL tumor infiltrating LYMPHOCYTES pulmonary ADENOCARCINOMA clinical significance 对照组 肿瘤浸润淋巴细胞 全身免疫反应 systemic IMMUNE IMMUNE system 定性定量分析 流式细胞术 临床意义 

分 类 号：R734.2[医药卫生—肿瘤]