实验性脑积水的发病机制及其相关基因的研究进展  

Research advances on associated genes and pathogenesis of hydrocephalus

作　　者：周佳君[1] 丁美萍[1] 刘建仁[1] 

机构地区：[1]浙江大学医学院附属第二医院神经内科,浙江杭州310009

出　　处：《浙江大学学报（医学版）》2010年第6期644-649,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金资助项目(30600193);浙江省科技厅钱江人才计划项目(2009R10022);浙江省卫生厅优秀青年科技人才专项基金资助项目(2004QN012)

摘　　要：脑积水是一种由于脑脊液吸收、分泌和循环障碍导致脑室系统扩大为主要病理特征的疾病。目前为止,脑积水的病理机制主要分为3种,即脉络丛产生脑脊液过多;脑脊液吸收障碍和脑积液循环受阻。然而,对于脑积水的病因和分子机制依然不清。随着基因工程的发展,基因敲除技术得到广泛应用,越来越多的研究证实,基因遗传在脑积水的发生中起着主要作用。Hydrocephalus is a common medical condition characterized by abnormalities in the secretion,circulation or resorption of cerebrospinal fluid(CSF),resulting in ventricular dilatation.The pathogenetic mechanism for the hydrocephalus is attributed to:the overproduction of CSF by the choroid plexus;the defect in CSF absorption and obstruction of CSF flow in the cerebral ventricles.However,the underlying etiology is poorly understood.With the development of genetic engineering,a growing body of evidence indicates that genetic factors play an essential role in the pathogenesis of hydrocephalus.It is the aim of this review to summarize these findings.

关 键 词：脑积水/病因 多因子遗传 小鼠 基因敲除 

分 类 号：R742.7[医药卫生—神经病学与精神病学]