nm23基因蛋白及组织蛋白酶D与乳腺癌转移的关系  

The relationship between expression of nm23 and cathepsin-D to metastasis of breast cancer

作　　者：赵广文[1] 赵容杰[2] 赵正林[3] 金相赞 梁在夏 李宗录 

机构地区：[1]延边大学附属医院烧伤整形外科,吉林延吉133000 [2]牡丹江医学院药理学教研室,黑龙江牡丹江157011 [3]牡丹江医学院生物化学教研室,黑龙江牡丹江157011 [4]大邱韩医科大学韩医系

出　　处：《延边大学医学学报》2010年第3期166-169,共4页Journal of Medical Science Yanbian University

摘　　要：[目的]探讨nm23基因蛋白及组织蛋白酶D(Cath-D)在人乳腺癌组织中的表达及其与乳腺癌转移的关系.[方法]应用免疫组织化学染色方法观察43例乳腺癌组织的nm23基因蛋白及Cath-D的表达.[结果]nm23蛋白和Cath-D的表达与乳腺癌患者的年龄、绝经前后、肿瘤大小、组织学类型及临床病理分期无关,而与组织学分级、淋巴结转移、复发及转移、生存期有相关性.[结论]检测nm23基因蛋白与Cath-D的表达可作为乳腺癌研究的重要指标,对乳腺癌的转移与预后判定有重要意义.OBJECTIVE To study the expressions of nm23 protein and cathepsin-D in breast cancer and its relationship with the metastasis.METHODS The expression of nm23 protein and cathepsin-D in 43 cases of breast cancer tissues were detected by using immunohistochemistry.RESULTS The expressions of nm23 protein and cathepsin-D were no significant relationship with the ages of patients,premenopause or postmenopause,size of tumor,histological type and the clinicopathological staging,but obvious association with histological grading,recurrence and transferation,lymph node metastasis and life span of patients.CONCLUSION The expressions of nm23 protein and cathepsin-D are as important makers for breast cancer,metastasis of breast cancer and prognosis of patients.

关 键 词：NM23基因蛋白 组织蛋白酶 乳腺癌转移 关系 breast cancer 乳腺癌组织 免疫组织化学染色 表达 临床病理分期 组织学类型 组织学分级 乳腺癌患者 淋巴结转移 肿瘤大小 预后判定 绝经前后 方法观 NM23蛋白 生存期 指标 

分 类 号：R[医药卫生]