羊脾多肽对小鼠免疫功能的影响  

Experimental study on imune function of spleen polypeptides

作　　者：李茂辉[1] 卢桂华[2] 赵卓夫 江宁[3] 徐立民[3] 

机构地区：[1]沈阳医学院预防医学系卫生化学教研室,沈阳110034 [2]辽宁省疾病预防控制中心 [3]沈阳海汇天成生物科技有限公司

出　　处：《中国公共卫生》2005年第9期1099-1100,共2页Chinese Journal of Public Health

摘　　要：目的探讨羊脾多肽对小鼠免疫功能的影响。方法分别以1,3,5g/(kg·d)羊脾多肽给小鼠连续灌胃30d后,检测各项免疫指标。结果羊脾多肽能使小鼠脾、胸腺增重,明显刺激小鼠的脾淋巴细胞增值,促进小鼠迟发型变态反应作用,提高小鼠抗体生成细胞数,提高小鼠的血清溶血素水平,但促进小鼠单核-巨噬细胞碳廓清作用不明显,增强小鼠的单核-腹腔巨噬细胞吞噬能力,有效提高小鼠自然杀伤细胞活性。结论羊脾多肽具有明显增强免疫力作用。Objective To study the effect of sheep spleen polypeptides on immune function. Methods Sheep spleen function was consecutively orally given to mice with the doses of 1,3, 5g/（kg·d） for 30 days and then immune indexes were determined. Results Sheep spleen polypeptides could significantly stimulate multiplication and transformation of mice＇ s spleen lymphocytes; increased markedly the weight of spleen and the thymus; promoted delayed hypersensitivity; increased the quantity of antibody-producing cells;increased the level of serum hemolysin;promoted the expurgation effect and the phagocytic function of monocyte/macrophage and increased the activity of natural killer.Conclusion Sheep spleen polypeptides can markedly increase immune function in mice.

关 键 词：羊脾多肽 免疫功能 脾 胸腺 

分 类 号：R151.3[医药卫生—营养与食品卫生学]