甘油氯化钠注射液细菌内毒素检查法的研究  

Study of bacterial endotoxin test for compound glycerin injection

作　　者：张浩[1] 张大萍[1] 林玉洪[1] 王震[1] 

机构地区：[1]蚌埠医学院第一附属医院药剂科,安徽蚌埠233004

出　　处：《淮海医药》2005年第6期438-439,共2页Journal of Huaihai Medicine

摘　　要：目的介绍细菌内毒素法对甘油氯化钠注射液热原的研究。方法应用鲎试剂检查甘油氯化钠注射液的热原,观察甘油氯化钠注射液对细菌内毒素检查法的干扰现象。结果甘油氯化钠注射液稀释2倍对细菌内毒素检查法无干扰行为。结论对甘油氯化钠注射液进行2倍稀释以0.5EU/ml的鲎试剂检查其热原是可行的。Objective To introduce a method to study the bacterial endotoxin test for detecting pyrogen in compound glycerin injection. Methods Limulus reagent was applied to detect pyrogen in compound glycerin injection and interference of compound glycerin injection in the process of bacterial endotoxin test was observed. Results Compound glycerin injection in 2-fold dilution had no interference in the bacterial endotoxin test. Conclusion Compound glycerin injection in 2-fold dilution applied in 0.5 EU/ ml limulus reagent in detection of its pyrogen is feasible.

关 键 词：甘油氯化钠注射液 细菌内毒素 鲎试剂 

分 类 号：R944.11[医药卫生—药剂学]