P53、Ras基因突变及HPV感染与膀胱癌的关系  

P53,Ras genes,HPV and bladder carcinoma

作　　者：李一伟[1] 黄健文[1] 翁景萱[1] 

机构地区：[1]福建医学院病理教研室

出　　处：《中华泌尿外科杂志》1996年第5期259-262,共4页Chinese Journal of Urology

基　　金：国家教委优秀青年教师基金;福建省教委科研基金

摘　　要：应用分子生物学方法检测３２例膀胱移行上皮癌中Ｐ５３、Ｋ－ｒａｓ、ＨＰＶ基因，发现有３４．４％的膀胱癌Ｐ５３基因突变，２１．９％膀胱癌Ｋ－ｒａｓ基因突变，６．３％膀胱癌ＨＰＶ阳性。说明膀胱移行上皮癌的发生与Ｐ５３、Ｒａｓ基因突变及ＨＰＶ感染有关。膀胱癌的发生是多种基因的变化通过多种途径引起的。cases of transitional cell carcinoma of bladder were detected for P53,K-ras genes and HPV using molecular biologic techniques.P53 mutation was observed in 34.4%,K-ras mutation in 21.9% and HPV-positive in 6.3%.The results revealed that bladder carcinoma was related to the mutation of P53 and ras genes and to the HPV infection.It was postulated that the pathogenesis of bladder carcinoma was related to the change of various genes through different pathway.

关 键 词：膀胱肿瘤 癌 基因 乳头状瘤病毒 P53 RAS 

分 类 号：R737.140.3[医药卫生—肿瘤] R730.231.3[医药卫生—临床医学]