胃癌高发区玉米面的致突变研究  

MUTAGENICITY OF CORN EXTRACTS FROM GASTRIC CANCER OF HIGH RISK AREA

作　　者：高泽立[1] 谢同欣[1] 王风荣[1] 高振强[1] 张振东[1] 米建民 刘兵 马洪义 

机构地区：[1]河北医学院基础所病理室 [2]赞皇县胃癌防办

出　　处：《肿瘤》1989年第4期157-159,共3页Tumor

摘　　要：河北省赞皇县是胃癌高发区,胃癌年平均死亡率为59/10万。赞皇县不同地理环境的行政乡胃癌死亡率相差悬殊。如西南部石咀头乡为84.47/10万、楼底乡为126.95/10万。东北部的张楞乡为28.11/10万、清河乡为32.85/10万。我们发现胃癌高发区的石咀头乡、楼底乡为深山区,当地居民主食为玉米。玉米收获后不脱粒,晒干后堆放房顶。Mutsgenicity of corn extracts collected from high risk area of gastric cancer inZanhuang county was studied with micronucleus test and unscheduled DNA synthesisassay (UDS). TLe results showed that the micronucleus rates in NIR mice induced bycorn extracts from high risk area was much higher than that from relative low riskarea. UDS CPM value was much higher in the high risk than that in relative low riskarea and displayed a significant dose-response relationship. Thus corn extracts fromZanhuang county may contain mutagens and/or carcinogens, which may be camefrom corn contaminated with Aspergilli.

关 键 词：胃肿瘤 玉米面 致突变 

分 类 号：R735.202[医药卫生—肿瘤]