多巴胺D_2受体基因-141C Ins/Del多态性与海洛因依赖的关系  

Relationship between DRD_2 receptor gene-141C Ins/Del polymorphism and heroin dependence

作　　者：邵春红[1] 李一峰[2] 江开达[3] 赵敏[3] 林凌[2] 宋立升[3] 徐一峰[3] 朱敏[3] 王秋颖[3] 周伟航 

机构地区：[1]复旦大学附属华山医院精神医学教研室,上海200040 [2]复旦大学生命学院遗传所 [3]上海市精神卫生中心 [4]上海市禁毒委员会办公室

出　　处：《中国行为医学科学》2005年第10期885-886,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的分析多巴胺D2受体(DRD2)基因-141CIns/Del多态是否与海洛因成瘾易感性有关。方法采用PCR-RFLP技术检测380名海洛因依赖者(依赖组)和275名健康对照者(对照组)的DRD2-141CIns/Del基因多态,比较依赖组和对照组DRD2-141CIns/Del多态基因型及等位基因频率是否有差异。结果依赖组与对照组相比,DRD2-141CIns/Del的基因型频率(Del/Del:4.3vs6.5;Ins/Del:24.8vs27.2;Ins/Ins:70.9vs66.2)和等位基因频率(Del:23.6vs20.2;Ins:76.4vs79.8)差异均无显著性(分别为2=2.789,P=0.248;2=2.103,P=0.210)。结论DRD2-141CIns/Del基因多态与海洛因成瘾易感性可能无关。Objective To analyze the relationship between DRD2 receptor gene-141C Ins/Del polymorphism and heroin dependence. Method The polymorphism of DRD2-141CIns/Del was detected by using PCR-RFLP for 380 heroin addicts who were abstinent （dependence group） and 275 normal controls （control group） using PCR-RFLP. The genotypes and alleles of DRD2-141CIns/Del between dependence group and control group. Results Compared with control group, no significant difference of genotypes and alleles of DRD2-141CIns/Del had been found in dependence group （ X^2 = 2. 789, P= 0. 248; X^2 =2. 103, P=0. 210,respectively）. Conclusion DRD2 receptor gene -141C Ins/Del polymorphism may have no association with the susceptibility of heroin dependence.

关 键 词：海洛因依赖 多巴胺D2受体 多态性 多巴胺D2受体 D2受体基因 海洛因依赖者 多态性 PCR-RFLP 等位基因频率 海洛因成瘾 基因型频率 基因多态 

分 类 号：R749.6[医药卫生—神经病学与精神病学]