精神分裂症、躁狂症家系血SOD测定及遗传学分析  

Determination of blood SOD activity in the family members of schizophrenics and mania patients and the genetic analysis

作　　者：余元勋[1] 祝文华[1] 黄邦良 杨文先 

机构地区：[1]安徽省优生优育遗传医学中心,铁道部四局四处医院

出　　处：《中国优生与遗传杂志》1996年第3期29-30,共2页Chinese Journal of Birth Health & Heredity

摘　　要：采用联苯三酚自氧化速率法测定了精神分裂症及躁狂症患者血ＳＯＤ活性，结果表明均较健康对照组显著增高（Ｐ＜０．０１）。精神分裂症患者家系一级亲属中血ＳＯＤ升高者占７１．４％，躁狂症患者家系一级亲属中血ＳＯＤ升高者６５．５％。从家系图分析等看出，这两种患者家系中血ＳＯＤ升高以常染色体显性遗传方式进行遗传。也讨论了在优生优育遗传咨询中的应用价值。the blood sod activities in the family members of schizophresis and mania were measured by C6H3(OH)3 self-oxidation rate method and were higher significantly than that of the normal subJects(p<0.01).The rate of family members with higher blood SOD activity in schizophrenics families was 71.4%,in mania family members 65.5%.After analysis of the patients family relationship maps,we found that in the two kinds of patients families the higher blood SOD activity was a character inherited in autosome dominant type(AD).

关 键 词：精神分裂症 躁狂症 超氧化物歧化酶 遗传学分析 

分 类 号：R749.302[医药卫生—神经病学与精神病学] R749.410.2[医药卫生—临床医学]