4－肟醚基喹唑啉类化合物的合成及其抗植物病毒TMV活性  

Synthesis of O-(4-Quinazolinyl)oxime Ethers and Their Antiviral Activity

作　　者：黄润秋[1] 李慧英[1] 马军安[1] 邱德文[1] 

机构地区：[1]南开大学元素有机化学研究所

出　　处：《高等学校化学学报》1996年第4期571-574,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：４－氯喹唑啉与取代芳香肟在碱存在下进行亲核取代反应，合成了１７种新型肟醚基喹唑啉衍生物，并对其结构进行了表征。生物活性测试表明，部分化合物抗植物烟草花叶病毒活性超过抗植物病毒商品药剂２，４－二氧六氢－１，３，５－三嗪。The O-(4_quinazplinyl)oxime ethers compounds were synthesized by the reactionof 4-chloro quinazoline and substituted aryl oximes under a base. Their structures were confirmed by means of elementary analysis. IR,1H NMR and MS. The preliminary bioassayshows that some compounds have higher antiviral activity against TMV than 1,3,5-triazine-hexahvdro-2,4-dione(DHT);CompoundsⅠ_6 and Ⅰ_(11), at～0. 3 mmol/L, results in 60%and 65%inhibition of TMV in nicotiana tabacum leaves respectively, compared to 45% usingDHT, at0.9mmol/L.

关 键 词：喹唑啉 肟醚 抗植物病毒活性 生物活性 

分 类 号：S432.41[农业科学—植物病理学]