Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity  

作　　者：ZHANG, Yi-Chun CHEN, Ping-Tao GUAN, Hua-Shi LI, Ying-Xia 

机构地区：[1]Key Laboratory of Marine Drugs, The Ministry of Education of China, Marine Drug and Food Institute, Ocean University of China, Qingdao, Shandong 266003, China

出　　处：《Chinese Journal of Chemistry》2005年第11期1523-1529,共7页中国化学（英文版）

摘　　要：A series of new conjugates of indomethacin with phenolic anfioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidafion significantly, while 11b-11e and 13b-13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.A series of new conjugates of indomethacin with phenolic anfioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidafion significantly, while 11b-11e and 13b-13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.

关 键 词：antioxidant INDOMETHACIN ANTIINFLAMMATION CONJUGATE nonsteroidal antiinflammatory drugs （NSAID） 

分 类 号：TQ463[化学工程—制药化工]