Effect of Mifepristone on the Telomerase Activity in Chorion and Decidua during Early Pregnancy  

作　　者：Ge-qing XIA Ya-li XIONG Yong-hong SUN 

机构地区：[1]Department of Obstetrics and Gynecology, Union Hospital of Tongji Medical University, Wuhan 430022,China

出　　处：《Journal of Reproduction and Contraception》2004年第4期245-249,共5页生殖与避孕（英文版）

摘　　要：Objective To investigate telomerase activity in chorion and decidua from abortion induced by mifepristone incorporated with misoprostol at early pregnancy. Methods TRAP-SYBR Green assay was used to detect the expression of telomerase. Forty specimen were obtained from medicinal abortion （experiment group） and forty were from normal induced abortion （control group）. Results Positive expression of chorion telomerase was significantly different between the experimental group （28%, 11/40） and the control group （73%, 29/40） （P〈0.05）. While in decidua, the positive rate was 28% （11/40） in the experimental group and 20% （9/40） in the control group, there was no significant difference （P〉0.05）. Conclusion It is suggested that miferistone may significantly decrease the telomerase activity in chorion but not in decidua.Objective To investigate telomerase activity in chorion and decidua from abortion induced by mifepristone incorporated with misoprostol at early pregnancy. Methods TRAP-SYBR Green assay was used to detect the expression of telomerase. Forty specimen were obtained from medicinal abortion （experiment group） and forty were from normal induced abortion （control group）. Results Positive expression of chorion telomerase was significantly different between the experimental group （28%, 11/40） and the control group （73%, 29/40） （P〈0.05）. While in decidua, the positive rate was 28% （11/40） in the experimental group and 20% （9/40） in the control group, there was no significant difference （P〉0.05）. Conclusion It is suggested that miferistone may significantly decrease the telomerase activity in chorion but not in decidua.

关 键 词：MIFEPRISTONE early gestation abortion CHORION DECIDUA TELOMERASE 

分 类 号：R714.1[医药卫生—妇产科学]