手性季铵盐(C_(12)O-PDBAC)的合成、表征及抑菌活性  

Synthesis,Characterization and Bacteriostatic Activities of Chiral Quaternary Ammonium(C_(12)O-PDBAC) Salt

作　　者：梁芳珍[1] 赵建霞[1] 

机构地区：[1]山东师范大学化学化工与材料科学学院,山东济南250014

出　　处：《精细与专用化学品》2005年第20期14-15,25,共3页Fine and Specialty Chemicals

基　　金：山东师范大学自然科学基金资助项目

摘　　要：以月桂醇、二甲胺和环氧氯丙烷为起始原料,合成了(3-十二烷氧-2-羟丙基)二甲基苄基氯化铵(C12O-PDBAC),产品用丙酮-无水乙醇/石油醚多次重结晶,并通过元素分析、红外光谱和核磁共振氢谱对目标产物的结构进行了表征。抑菌试验结果表明,产品对金黄色葡萄球菌和大肠杆菌的最低抑菌浓度为40mmol/L。Starting with 1-dodecanol, dimethylamine and epichlorohydrin, （3-dodecoxy-2-hydroxypropyl） dimethyl benzyl ammonium chloride （ C12 O-PDBAC） was synthesized, then it was recrystallized with acetone-absolute alcohol/naphtha for several times. And the structure of title product was characterized by elemental analysis, IR and ^1H-NMR. The test showed that the minimal bacteriostatic concentration of product against S L Aureus and E Coli was 40 mmol/L.

关 键 词：月桂醇 环氧氯丙烷 手性季铵盐 抑菌活性 合成 表征 金黄色葡萄球菌 核磁共振氢谱 最低抑菌浓度 苄基氯化铵 

分 类 号：TQ455[化学工程—农药化工]